The foot formation stimulating peptide pedibin is also involved in patterning of the head in hydra
نویسنده
چکیده
Pedibin, a peptide of 21 amino acids, has been shown to stimulate foot formation in hydra, one of the simplest metazoan animals. The data presented here show that pedibin is synthesized as a precursor of 49 amino acids. A putative cleavage site precedes the peptide as purified from hydra tissue. The precursor, like pedibin, accelerates foot regeneration. Pedibin transcripts are concentrated in the foot region of hydra as expected, but are also present in the head region accumulating in the tentacle bases. The early appearance of pedibin transcripts during phases of cell fate specification like budding and regeneration implies that in hydra, pedibin plays an important role in patterning processes of foot and head. This is confirmed by the finding that pedibin also stimulates bud outgrowth.
منابع مشابه
Control of foot differentiation in Hydra: Phylogenetic footprinting indicates interaction of head, bud and foot patterning systems
Homeodomain transcription factor CnNK-2 seems to play a major role in foot formation in Hydra. Recently, we reported in vitro evidence indicating that CnNK-2 has autoregulatory features and regulates expression of the morphogenetic peptide pedibin. We proposed that CnNK-2 and pedibin synergistically orchestrate foot differentiation processes. Here, we further analyzed the regulatory network con...
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The foot of the simple metazoan Hydra is a highly dynamic body region of constant tissue movement, cell proliferation, determination and differentiation. Previously, two genes have been shown to participate in the development and differentiation of this body region: homeodomain factor CnNK-2 and signal peptide pedibin [Dev. Biol. 180 (1996) 473; Development 126 (1999) 517; Development 122 (1996...
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ورودعنوان ژورنال:
- Mechanisms of Development
دوره 106 شماره
صفحات -
تاریخ انتشار 2001